Chronic Lymphocytic Leukemia - Blood Cell Study
Characterization of Proliferating Compartment in B-CLL Patients and in Healthy Aging Subjects (GAC 0117)
Protocol ID
Protocol Description
In patients with leukemia, blood cells (both normal cells and leukemic cells) are produced in the bone marrow to replace cells that have died or been removed. This process of replacement is called cell turnover.
This study will look at the cell turnover of leukemia cells in patients with chronic lymphocytic leukemia (CLL) using a method to measure the production and destruction rates of cells. A correlation between cell birth rates and CLL disease activity and progression appears to exist, which may help identify patients at risk for worsening disease in advance of clinical deterioration.
Another group of healthy volunteers and unaffected family members who do not have CLL will be used as a control group for comparison.
Eligibility Criteria
Patients with chronic lymphocytic leukemia (CLL), unaffected family members who do not have CLL and healthy volunteers
Primary Investigator(s)
- Nicholas Chiorazzi, MD