Acute Myeloid Leukemia - Clinical Trial (06-118T)

CALGB 10503:  Phase II Study of Maintenance Therapy with Decitabine (NSC #127716, IND #50733) Following Standard Induction and Cytogenetic Risk-Adapted Intensification in Previously Untreated Patients with AML<60 Years

Protocol ID

06-118T

Protocol Description

The purpose of this study is to find out what effects (good and bad) treatment with a drug known as decitabine has on patients and their leukemia after they have received standard combination chemotherapy treatment for acute myeloid leukemia (AML). Standard combination chemotherapy will be followed by the experimental part of this study, treatment with decitabine to prevent relapse. Decitabine is FDA approved, however its use in this study is investigational. Decitabine has shown to have anti-leukemia activity in patients with active leukemia, but its role in preventing relapse in patients who are in remission (that is, who show no evidence of leukemia) has not been studied.

Eligibility Criteria

Patients with acute leukemia

Primary Investigator(s)

  • Jonathan Kolitz, MD

Contact Information

Jennifer Cuevo, RN
(516) 562-8920
jcuevo@nshs.edu

Last Update

November 11, 2009
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