Wilms Tumor Study
COG#AREN0533 Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumor
Protocol ID
08-233
Protocol Description
Chemotherapy and radiation have side effects and late effects, so study doctors are trying to find out the amount of treatment to give subjects that will treat their cancer and at the same time have less of these effects. Late effects are health problems that happen to patients later in life because of the drugs or radiation used to treat their cancer.
The overall goal of this study is to find out:
- If subjects with Wilms tumor that has spread only to their lungs can be treated without having radiation therapy to their lungs. Subjects whose lung tumors go away completely after the first six weeks of standard chemotherapy will not have to have radiation therapy to their lungs.
- If subjects with Wilms tumor that has spread only to their lungs whose lung tumors do not go away after the first six weeks of standard chemotherapy for Wilms tumor can be treated by using two additional chemotherapy drugs, plus radiation therapy to their lungs.
- If subjects who have Wilms tumor that has spread to other parts of the body in addition to or instead of in the lungs, can be treated by using two additional chemotherapy drugs along with the standard drugs, and standard radiation therapy to all sites of disease.
- If some genetic information about the tumor cells can help us put subjects in the experimental treatment group.
Eligibility Criteria
Children and adolescents with Wilms tumor
Primary Investigator(s)
- Arlene Redner, MD
Contact Information
Christine Grabowski, CCRP
(718) 470-3401
grabowsk@lij.edu
(718) 470-3401
grabowsk@lij.edu