Brain cell injury and death are believed to cause the symptoms of Huntington's disease (HD).  A major factor in the brain cell death is thought to be a lack of normal levels of cell energy and that brings about harmful brain substances called free radicals. 

Creatine is a dietary supplement believed to help the body produce energy.  It is an investigational drug for HD.  High doses of creatine may help protect brain cells in people who have HD by improving the levels of cell energy.  Creatine has been studied at high doses in a small number of HD patients who were able to safely take it for over three years.  It is not yet known if creatine will help people with HD.  Creatine has not been approved by the US Food and Drug Administration (FDA) for treating any disease.

The purpose of this study is to assess whether high doses of creatine can slow down the worsening of HD symptoms that occurs over time.  We will also develop a better understanding of side effects that can occur while taking creatine, assess its safety in long-term use and learn more about how creatine affects the  body and the brain.