Southside's surgeons treat most types of cancer, often using minimally invasive techniques to ease and shorten recovery. Procedures as varied as lung or colon cancer surgery can be done using these techniques. Surgeons can also use minimally invasive technology to carefully examine organs and tumors during surgery before taking the next steps.

Because surgeons at Southside take sentinel node biopsies to determine the extent of breast cancer and melanoma, they may be able to perform less-extensive surgery to remove cancerous tissue. The hospital's plastic and reconstructive surgeons play an important role in surgical treatment for cancer patients, in particular for breast cancer.