Ping Wang, MD
Trauma and Sepsis
Ping Wang, MD
Vice Chairman for Research, Department of Surgery
Brief Description of Research
The main research objectives of our laboratory are directed toward the understanding of mechanisms responsible for cell and organ dysfunction after trauma/hemorrhage and during sepsis as well as their correction. Specifically, we are focusing on improvement of organ function after severe hypovolemia and the role of the sympathetic nervous system and parasympathetic nervous system in sepsis.
We also focus on regulation of age-related inflammation in septic shock. Moreover, the role of MFG-E8 in promoting apoptotic cell phagocytosis is currently under investigation. In addition, preclinical trials have been conducted to develop novel therapies for hemorrhage, ischemia/reperfusion, and sepsis.
Ping Wang, MD
Vice Chairman for Research, Department of Surgery
Chief, Division of Surgical Research
North Shore University Hospital & Long Island Jewish Medical Center
Investigator and Director, Laboratory of Surgical Research
The Feinstein Institute for Medical Research
Professor of Surgery, Albert Einstein College of Medicine
350 Community Drive
Manhasset, NY 11030
Phone: (516) 562-3411
Fax: (516) 562-1022
Project 1 Modulation of hepatic function in sepsis
Project 2 Mediators and cardiovascular response in sepsis
Project 3 Vasoactive mediators in hemorrhage and gut ischemia/reperfusion
Project 4 Apoptosis and its clearance
Project 5 Cytochrome P-450 enzyme systems in shock
Project 6 Preclinical trials of novel therapeutic agents
Wayne Chaung, PhD, Research Scientist
Weifeng Dong, MS, Sr. Research Assistant
Youxin Ji, MD, Sr. Research Assistant
Sakdhispol Katanyutanon, MD, GI Fellow
Hidefumi Komura, MD, PhD, Postdoctoral Research Fellow
Subir R. Maitra, PhD, Sr. Research Scientist/Visiting Professor
Michael Miksa, MD, Research Scientist
Xiaoling Qiang, MD, PhD, Research Scientist
Madeline Quinn, Administrative Supervisor
Kavin G. Shah, MD, Surgical Resident
Asha Varghese, PhD, Research Scientist
Ping Wang, MD, Investigator/Professor
Rongqian Wu, MD, PhD, Sr., Research Scientist/Assistant Professor
Fangming Zhang, MD, PhD, Research Associate
Mian Zhou, MD, Sr. Research Scientist
Current Grant Support (Dr. Wang has received $10 million NIH support since 1995)
5R01 GM053008-11 Ping Wang, Principal Investigator 12-15-05 to 11-30-09
Agency: NIH/NIGMS "Modulation of Hepatocellular Function in Early Sepsis"
2R01 GM057468-10A1 Ping Wang, Principal Investigator 09-01-07 to 11-31-11
Agency: NIH/NIGMS "Sepsis and Mediators: the Role of MFG-E8”
5R01 HL076179-04 Ping Wang, Principal Investigator 02-01-04 to 01-31-09
Agency: NIH/NIGMS "Improvement of Organ Function after Severe Hypovolemia”
5R01 AG028352-02 Ping Wang, Principal Investigator 08-01-06 to 05-31-11
Agency: NIH/NIA "Regulation of Age-Related Inflammation in Septic Shock”
1. Rongqian Wu, MD, PhD: Surgery Specialty Award, Society of Critical Care Medicine, 2004
2. Aqeel M. Siddiqui, MD: New Investigator Competition Award (Finalist), Shock Society, 2004
3. Rongqian Wu, MD, PhD: Educational Scholarship Award, Society of Critical Care Medicine, 2005
4. Michael Miksa, MD: New Investigator Competition Award (First Place), Shock Society, 2005
5. Anusha Kambhampaty (High School Senior): Intel Semifinalist Award, 2006
6. Juntao Yang, MD, PhD: Travel Award, Shock Society, 2007
Recent Peer-Reviewed Publications (Selected from more than 230 publications)
1. Wu R, Cui X, Dong W, Zhou M, Simms HH, Wang P: Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Ann Surg 242: 115-123, 2005.
2. Wu R, Dong W, Zhou M, Cui X, Simms HH, Wang P: Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1 . Cardiovasc Res 68:318-326, 2005.
3. Hu M, Du Q, Vancurova I, Lin X, Miller EJ, Simms HH, Wang P: Proapoptotic effect of curcumin on human neutrophils: activation of the P38 mitogen-activated protein kinase pathway. Crit Care Med 33:2571-2578, 2005.
4. Hu M, Lin X, Du Q, Miller EJ, Wang P, Simms HH: Regulation of polymorphonuclear leukocyte apoptosis: the role of lung endothelium-epithelium bilayer transmigration. Am J Physiol Lung Cell Mol Physiol 288:L266-L274, 2005.
5. Wu R, Dong W, Zhou M, Cui X, Simms HH, Wang P: A novel approach to maintain hemodynamic stability after hemorrhagic shock: beneficial effects of adrenomedullin and its binding protein. Surgery 137:200-208, 2005.
6. Cui X, Wu R, Zhou M, Dong W, Ulloa L, Yang H, Wang H, Tracey KJ, Simms HH, Wang P: Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. Crit Care Med 33:391-398, 2005.
7. Zhou M, Das P, Simms HH, Wang P: Gut-derived norepinephrine plays an important role in upregulating IL-1ß and IL- 10. Biochim Biophys Acta 1740:446-452, 2005.
8. Wang H, Li W, Li J, Rendon-Mitchell B, Ochani M, Ashok M, Yang L, Yang H, Tracey KJ, Wang P, Sama AE: The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr 136:360-365, 2006.
9. Cui Y, Ji Y, Wu R, Zhou M, Wang P: Adrenomedullin binding protein- 1 is downregulated during polymicrobial sepsis in the rat. Int J Mol Med 17:925-929, 2006.
10. Miksa M, Wu R, Dong W, Das P, Yang D, Wang P: Dendritic cell-derived exosomes expressing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 25:586-593, 2006.
11. Siddiqui AM, Cui X, Wu R, Dong W, Zhou M, Hu M, Simms HH, Wang P: The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-y (Feature Article). Crit Care Med 34:1874-1882, 2006.
12. Wu R, Cui X, Dong W, Zhou M, Simms HH, Wang P: Suppression of hepatocyte CYP lA2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines. Int J Mol Med 18:339-346, 2006.
13. Higuchi S, Wu R, Zhou M, Ravikumar TS, Wang P: Downregualtion of hepatic cytochrome P450 isoforrns and PPAR-y: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis. J Surg Res 137:46-52, 2007.
14. Carrizo GJ, Wu R, Cui X, Dwivedi AJ, Simms HH, Wang P: Adrenomedullin and adrenomedullin binding protein- 1 downregulate inflammatory cytokines and improve survival after gut ischemia-reperfusion. Surgery 141:245-253, 2007.
15. Wu R, Dong W, Zhou M, Simms HH, Marini CP, Ravikumar TS, Wang P: Adrenomedullin and adrenomedullin binding protein- 1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Crit Care Med 35: 912-918, 2007.
16. Li W, Li J, Ashok M, Wu R, Chen D, Yang L, Yang H, Tracey KJ, Wang P, Sama AE, Wang H: A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late- acting proinflammatory mediator, HMGB- 1. J Immunol 178:3856-3864, 2007.
17. Wu R, Dong W, Cui X, Zhou M, Simms HH, Ravikumar TS, Wang P: Ghrelin downregulates pro-inflammatory cytokines in sepsis via activation of the vagus nerve. Ann Surg 245:480-486, 2007.
18. Jacob A, Zhou M, Wu R, Halpern VJ, Ravikumar TS, Wang P: Proinflammatory cytokines from Kupffer cells downregulate hepatocyte expression of adrenomedullin binding protein- 1. Biochim Biophys Acta 1772:766-772, 2007.
19. Dwivedi AJ, Wu R, Nguyen E, Higuchi S, Wang H, Krishnasastry K, Marini CP, Ravikumar TS, Wang P: Adrenomedullin and adrenomedullin binding protein- 1 prevent acute lung injury after gut ischemia- reperfusion. J Am Coll Surg 205:284-293, 2007.
20. Zhou M, Maitra SR, Wang P: Adrenomedullin and adrenomedullin binding protein- 1 protect endothelium-dependent relaxation in sepsis. Mol Med 13:488-494, 2007.
21. Wu R, Dong W, Zhou M, Zhang F, Marini CP, Ravikumar TS, Wang P: Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med , July 12, 2007 (Epub ahead of print).
22. Miksa M, Armin D, Wu R, Ravikumar TS, Wang P: Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol Med , July 31, 2007 (Epub ahead of print).
23. Miksa M, Wu R, Cui X, Dong W, Das P, Simms HH, Ravikumar TS, Wang P: Vasoactive hormone adrenomedullin and its binding protein after injury: anti-inflammatory effects by upregulating PPAR-y. J Immunol , 2007 (in press).
24. Wu R, Zhou M, Das P, Dong W, Ji Y, Yang D, Miksa M, Ravikumar TS, Wang P: Ghrelin inhibits sympathetic nervous activity in sepsis. Am J Physiol Endocrinol Metab (revised and pending for acceptance).
25. Zhou M, Wu R, Dong W, Jacob A, Wang P: Proinflammatory cytokine but not endotoxin downregulates hepatic peroxisome proliferator-activated receptor-y in sepsis. Am J Physiol Regul Integr Comp Physiol (revised and pending for acceptance).