Weng-Lang Yang, PhD

Surgical Oncology

Weng-Lang Yang, PhD

Brief Description of Research

Our laboratory has two major research interests. First, we are working to understand the cellular responses of cancer cells to surgical ablative modalities, focusing on cryosurgery and radiofrequency ablation, and lead to develop rational strategies in combination of ablations and other therapies for enhancing the efficacy of treating patients with solid tumors. Second, we are trying to identify and characterize genes that are involved in cancer progression from primary colorectal tumor to liver metastases. We have identified dysregulation of bone morphogenetic proteins (BMP) during colorectal tumor progression. We are now studying biological functions of BMPs in contributing the malignancy of colorectal cancer cells. We are also exploring the potential of applying BMP as a prognostic marker and targeting BMP signaling pathway to inhibit tumor metastasis.

Contact Information

Weng-Lang Yang, PhD
Assistant Investigator
Division of Surgical Research
Department of Surgery

North Shore-Long Island Jewish Medical Center
Assistant Professor of Surgery
Albert Einstein College of Medicine
350 Community Drive
Manhasset, NY 11030

Phone: (516) 562-2835

Fax: (516) 562-1022

Email: wlyang@nshs.edu


Current Projects

Project 1 Clinical trial: A phase II study of GM-CSF in combination with radiofrequency ablation and chemotherapy in liver metastasis from colorectal cancer
Project 2 Molecular mechanisms of bone morphogenetic protein signaling pathway in regulating colorectal cancer progression
Project 3 Development of bone morphogenetic protein as a prognostic marker to monitor the malignancy of colorectal cancer


Laboratory Members

Haiyun Deng, MD Research Fellow
Hauli Dong, MD Research Technician


Recent Peer-Reviewed Publications

1. Hanai A, Yang WL, and Ravikumar, TS: Induction of apoptosis in human colon carcinoma cells HT29 by sublethal cryo-injury: mediation by cytochrome c release. Int J Cancer 93:526-533, 2001.

2. Yang WL, Addona T, Nair DG, Qi L, and Ravikumar TS: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondria dysfunction. Int J Cancer 103:360-369, 2003.

3.Yang WL, Yang-Biggs G, Wu Y, Ye X, Gallos G, Owen RP, and Ravikumar, TS: Development of resistance by combination of heat treatment with cisplatin and hydroxyurea in FaDu squamous carcinoma cells. J Surg Res 111:143-151, 2003.

4. Yang WL, Nair DG, Makizumi R, Gallos G, Ye X, Sharma RR, and Ravikumar TS: HSP70 is induced in mouse human colon tumor xenografts after sublethal radiofrequency ablation. Ann Surg Oncol 11:399-406, 2004.

5. Sharma RR, Ravikumar TS, Raimo D, and Yang WL: Induction of p21WAF1 expression protects HT29 colon cancer cells from apoptosis induced by cryo-injury. Ann Surg Oncol (in press) 2005.

6. Yang WL, Makizumi R, Dong H, and Ravikumar TS: Associated changes of bone morphogentic protein levels in human colorectal cancer during tumor progression. J. Am Coll Surg (in press, abstract) 2005.

7. Makizumi R., Yang WL, Sharma RR, Dong, H, and Ravikumar TS: Alternation of drug sensitivity in human colon cancer cells after exposure to high temperature (submitted).

Last Update

February 5, 2010
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