Health Discoveries in Neurovascular and Stroke

Manipulating chemical reaction may aid stroke recovery

November 5, 2010
A study published in the journal Nature found that stroke recovery may be improved by turning off a chemical reaction that takes place right after a stroke occurs and determining when brain repair therapy will have the greatest effect.


A UCLA research team found that while a post-stroke rise in the chemical reaction known as "tonic inhibition" may limit immediate brain damage, it may also slow down the brain's recovery.


"It was surprising that we could easily manipulate tonic inhibition in the brain after stroke to restore it back to a normal, 'non-stroke' level and, in doing this, enhance behavioral recovery," said Dr. Tom Carmichael, a member of the UCLA Stroke Center. "An important element in stroke treatment is the timing of drug delivery. We found that blocking tonic inhibition too early could produce cell death, but by delaying treatment to three days after stroke, it promoted functional recovery without altering the stroke size."


The North Shore University Hospital in Manhasset, New York, has been certified for disease-specific care for stroke from the Joint Commission. It was the first hospital in the North Shore-LIJ Health System to receive the certification.
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