Clozapine is an antipsychotic used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life and strong or inappropriate emotions) in patients who have not been helped by other medications or who have tried to kill themselves and are likely to try to kill or harm themselves again. Clozapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.

Clozapine comes as a tablet or an orally disintegrating tablet (a tablet that dissolves quickly) to take by mouth. It is usually taken one to three times a day. Patients undergoing clozapine treatment should take clozapine at around the same time(s) every day. It is important to follow the directions on the prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Patients should take clozapine exactly as directed. They should not take more or less of it, or take it more or less often, than prescribed by a doctor.

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