Gastrointestinal pathology


The gastrointestinal pathology service offers broad experience in adult gastrointestinal and pancreatic disease, including FNA, endoscopic biopsies and surgical specimens. Our pathology group provides the highest quality GI pathology diagnoses, including second opinion, made exclusively by one of our trained gastrointestinal and liver pathologists. As a group we are available to answer your questions and concerns about diagnoses at all times.


The gastrointestinal pathologists at North Shore-LIJ Health System are surgical pathologists who provide real-time consultations on challenging case materials. The service conducts routine intra-service quality review and maintains routine contact with clinical teams in this subspecialty area.


James M. Crawford, MD, PhD

  • Senior Vice President & Executive Director, Laboratory Services,
    North Shore-LIJ Health System
  • Chair of Pathology & Laboratory Medicine,
    North Shore University Hospital
  • Chair of Pathology & Laboratory Medicine,
    Long Island Jewish Medical Center
  • Chair of Pathology & Laboratory Medicine,
    Hofstra North Shore-LIJ School of Medicine
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Cathy Qiuxi Fan, MD, MBBS

Timely results

The diagnostic reports for endoscopic and needle biopsies are routinely completed in 24-48 hours.



Surgical resections, endoscopic and laparoscopic biopsies and needle core biopsies for diseases including: gastroesophageal reflux, Barrett’s esophagus, gastritis, stomach cancer, enteritis, colorectal polyps and cancer, inflammatory bowel disease, chronic hepatitis, cirrhosis, hepatocellular carcinoma, pancreatitis and cancer, and biliary tract disease.

  • Endoscopic gastrointestinal biopsies
  • Liver biopsies
  • Gastrointestinal, pancreatic, hepatobiliary tumor evaluation
  • Surgical biopsies and resections


  • Brushings and washings
  • Fine needle aspirations
  • Liquid-based technology with cell blocks, allowing the performance of special stains, immunohistochemistry, and molecular studies

Special Stains

  • Diff-Quik, Giemsa or Steiner for Helicobacter pylori
  • Complete liver panel (trichrome, reticulin, iron, PAS with diastase)
  • Others (calcium, bile, mucins, copper, Congo Red, GMS, AFB, PAS/Alcian blue, etc.)

Immunohistochemistry and Flow Cytometry

Complete panels, including:

  • DNA mismatch repair proteins for colorectal carcinoma (MLH1, MSH2, MSH6, PMS2)
  • Therapeutic marker for colorectal carcinoma (EGFR, including in situ hybridization)
  • Gastrointestinal stromal tumor profile
  • Organ-specific diagnostic markers
  • Prognostic markers (Ki-67, p53, etc.)
  • Complete lymphoma work-up including flow cytometry
  • Infectious agents (H. pylori, HBsAg, HBcAg, HSV, CMV, adenovirus, EBV in situ hybridization)

Molecular and Cytogenetic Testing

  • Southern blot, PCR, and FISH techniques for:
  • Screening for microsatellite instability in colorectal cancer
  • Typing of lymphoma
  • Ploidy studies
  • Irinotecan sensitivity (UGTIAI) [separate brochure available for specimen handling]